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Parks, John

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Item Type	Name
Academic Article	Dietary n-3 polyunsaturated fat increases the fractional catabolic rate of medium-sized HDL particles in African green monkeys.
Academic Article	Alteration of plasma HDL cholesteryl ester composition with transgenic expression of a point mutation (E149A) of human LCAT.
Academic Article	Isolation and characterization of high density lipoprotein apoproteins in the non-human primate (vervet).
Academic Article	Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice.
Academic Article	Negative charge at amino acid 149 is the molecular determinant for substrate specificity of lecithin: cholesterol acyltransferase for phosphatidylcholine containing 20-carbon sn-2 fatty acyl chains.
Academic Article	Dietary hydrogenated fat increases high-density lipoprotein apoA-I catabolism and decreases low-density lipoprotein apoB-100 catabolism in hypercholesterolemic women.
Academic Article	Amino acids 149 and 294 of human lecithin:cholesterol acyltransferase affect fatty acyl specificity.
Academic Article	Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential.
Academic Article	Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I.
Academic Article	HDLs in apoA-I transgenic Abca1 knockout mice are remodeled normally in plasma but are hypercatabolized by the kidney.
Academic Article	Intestinal ABCA1 directly contributes to HDL biogenesis in vivo.
Academic Article	Reduction in ABCG1 in Type 2 diabetic mice increases macrophage foam cell formation.
Academic Article	Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels.
Academic Article	Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment.
Academic Article	Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons.
Academic Article	Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function.
Academic Article	Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis.
Academic Article	Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism.
Academic Article	Myeloid differentiation primary response protein 88 couples reverse cholesterol transport to inflammation.
Academic Article	Lipotoxicity in diabetic nephropathy: the potential role of fatty acid oxidation.
Academic Article	Adipose tissue ATP binding cassette transporter A1 contributes to high-density lipoprotein biogenesis in vivo.
Academic Article	Hepatic ABCA1 and VLDL triglyceride production.
Academic Article	Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis.
Academic Article	Omega-3 fatty acids ameliorate atherosclerosis by favorably altering monocyte subsets and limiting monocyte recruitment to aortic lesions.
Academic Article	Effect of fish oil versus lard diets on the chemical and physical properties of low density lipoproteins of nonhuman primates.
Academic Article	Different kinetic fates of apolipoproteins A-I and A-II from lymph chylomicra of nonhuman primates. Effect of saturated versus polyunsaturated dietary fat.
Academic Article	Interactions of the carboxyl group of oleic acid with bovine serum albumin: a 13C NMR study.
Academic Article	Dietary polyunsaturated fat modifies low-density lipoproteins and reduces atherosclerosis of nonhuman primates with high and low diet responsiveness.
Academic Article	Inhibition of lecithin:cholesterol acyltransferase activity by synthetic phosphatidylcholine species containing eicosapentaenoic acid or docosahexaenoic acid in the sn-2 position.
Academic Article	Dietary fatty acid modification of HDL phospholipid molecular species alters lecithin: cholesterol acyltransferase reactivity in cynomolgus monkeys.
Academic Article	Dietary fish oil-induced decrease in low density lipoprotein binding to fibroblasts is mediated by apolipoprotein E.
Academic Article	Cytokines decrease apolipoprotein accumulation in medium from Hep G2 cells.
Academic Article	Dietary fish oil modification of cynomolgus monkey low density lipoproteins results in decreased binding and cholesteryl ester accumulation by cultured fibroblasts.
Academic Article	Glycosylation structure and enzyme activity of lecithin:cholesterol acyltransferase from human plasma, HepG2 cells, and baculoviral and Chinese hamster ovary cell expression systems.
Academic Article	Plasma cholesteryl ester transfer activity is modulated by the phase transition of the lipoprotein core.
Academic Article	Amino acid residue 149 of lecithin:cholesterol acyltransferase determines phospholipase A2 and transacylase fatty acyl specificity.
Academic Article	Long-chain polyunsaturated fatty acids in the sn-2 position of phosphatidylcholine decrease the stability of recombinant high density lipoprotein apolipoprotein A-I and the activation energy of the lecithin:cholesterol acyltransferase reaction.
Academic Article	Role of glutamic acid residues 154, 155, and 165 of lecithin:cholesterol acyltransferase in cholesterol esterification and phospholipase A2 activities.
Academic Article	Lysosomal acid lipase mutations that determine phenotype in Wolman and cholesterol ester storage disease.
Academic Article	In vivo contribution of LCAT to apolipoprotein B lipoprotein cholesteryl esters in LDL receptor and apolipoprotein E knockout mice.
Academic Article	Enhancement of scavenger receptor class B type I-mediated selective cholesteryl ester uptake from apoA-I(-/-) high density lipoprotein (HDL) by apolipoprotein A-I requires HDL reorganization by lecithin cholesterol acyltransferase.
Academic Article	Identification of the lipoprotein initiating domain of apolipoprotein B.
Academic Article	Prebeta high density lipoprotein has two metabolic fates in human apolipoprotein A-I transgenic mice.
Academic Article	ATP-binding cassette transporter AI and its role in HDL formation.
Academic Article	Hepatic ATP-binding cassette transporter A1 is a key molecule in high-density lipoprotein cholesteryl ester metabolism in mice.
Academic Article	Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo.
Academic Article	Effect of fish oil diet on hepatic lipid metabolism in nonhuman primates: lowering of secretion of hepatic triglyceride but not apoB.
Academic Article	Minimal lipidation of pre-beta HDL by ABCA1 results in reduced ability to interact with ABCA1.
Academic Article	Whole-body cholesterol metabolism in cholesterol-fed African green monkeys with a variable hypercholesterolemic response.
Academic Article	Echium oil reduces plasma lipids and hepatic lipogenic gene expression in apoB100-only LDL receptor knockout mice.
Academic Article	Mechanisms by which botanical lipids affect inflammatory disorders.
Academic Article	Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages.
Academic Article	Initial interaction of apoA-I with ABCA1 impacts in vivo metabolic fate of nascent HDL.
Academic Article	LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins.
Academic Article	Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis.
Academic Article	An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2.
Academic Article	Apolipoprotein M expression increases the size of nascent pre beta HDL formed by ATP binding cassette transporter A1.
Academic Article	ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation.
Academic Article	ABCG1 deficiency in mice promotes endothelial activation and monocyte-endothelial interactions.
Academic Article	A novel role for ABCA1-generated large pre-beta migrating nascent HDL in the regulation of hepatic VLDL triglyceride secretion.
Academic Article	An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells.
Academic Article	Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol.
Academic Article	The reactivity of plasma phospholipids with lecithin:cholesterol acyltransferase is decreased in fish oil-fed monkeys.
Academic Article	CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action.
Academic Article	Hepatic ABC transporters and triglyceride metabolism.
Academic Article	Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers.
Academic Article	The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence.
Academic Article	Myeloid cell-specific ABCA1 deletion protects mice from bacterial infection.
Academic Article	ATP-binding cassette transporter G1 intrinsically regulates invariant NKT cell development.
Academic Article	Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration.
Academic Article	Detection of immunological heterogeneity of an isolated, purified protein (vervet apolipoprotein A-I).
Academic Article	Metabolism of the serum amyloid A proteins (SSA) in high-density lipoproteins and chylomicrons of nonhuman primates (vervet monkey).
Academic Article	The ionization behavior of fatty acids and bile acids in micelles and membranes.
Academic Article	Hepatic ACAT activity in African green monkeys is highly correlated to plasma LDL cholesteryl ester enrichment and coronary artery atherosclerosis.
Academic Article	Interrelationships of alpha-tocopherol with plasma lipoproteins in African green monkeys: effects of dietary fats.
Academic Article	Decreased binding of apoA-I to phosphatidylcholine monolayers containing 22:6 n-3 in the sn-2 position.
Academic Article	Reduction of cholesterol absorption by dietary oleinate and fish oil in African green monkeys.
Academic Article	Low density lipoprotein particle size and core cholesteryl ester physical state affect the proton NMR magnetic environment of fatty acid methylene and methyl nuclei.
Academic Article	Alteration in apolipoprotein A-I 22-mer repeat order results in a decrease in lecithin:cholesterol acyltransferase reactivity.
Academic Article	The hydrophobic face orientation of apolipoprotein A-I amphipathic helix domain 143-164 regulates lecithin:cholesterol acyltransferase activation.
Academic Article	Effect of long chain polyunsaturated fatty acids in the sn-2 position of phosphatidylcholine on the interaction with recombinant high density lipoprotein apolipoprotein A-I.
Academic Article	Lipoprotein and cholesterol metabolism in diet-induced coronary artery atherosclerosis in primates. Role of cholesterol and fatty acids.
Concept	MAP Kinase Signaling System
Concept	Palmitic Acids
Concept	Fatty Acids, Omega-3
Concept	Biological Transport
Concept	Linoleic Acids
Concept	Egg Yolk
Concept	Citric Acid Cycle
Concept	Sialic Acids
Concept	Fatty Acids, Unsaturated
Concept	Trans Fatty Acids
Concept	Linoleic Acid
Concept	ATP-Binding Cassette Transporters
Concept	gamma-Linolenic Acid
Concept	Fatty Acids
Concept	Organic Anion Transporters, Sodium-Dependent
Concept	Amino Acids
Concept	Amino Acid Substitution
Concept	Amino Acid Sequence
Concept	Fatty Acid Desaturases
Concept	Receptors, Retinoic Acid
Concept	Eicosapentaenoic Acid
Concept	Fatty Acids, Monounsaturated
Concept	Repetitive Sequences, Nucleic Acid
Concept	Oleic Acids
Concept	Bile Acids and Salts
Concept	Docosahexaenoic Acids
Concept	Protein Transport
Concept	Fatty Acids, Omega-6
Concept	Arachidonic Acid
Concept	Glutamic Acid
Concept	Palmitic Acid
Concept	Mevalonic Acid
Concept	Oleic Acid
Academic Article	Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice.
Academic Article	Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis.
Academic Article	Myeloid cell-specific ABCA1 deletion does not worsen insulin resistance in HF diet-induced or genetically obese mouse models.
Academic Article	Lipid absorption defects in intestine-specific microsomal triglyceride transfer protein and ATP-binding cassette transporter A1-deficient mice.
Academic Article	Myeloid cell-specific ATP-binding cassette transporter A1 deletion has minimal impact on atherogenesis in atherogenic diet-fed low-density lipoprotein receptor knockout mice.
Academic Article	Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation.
Academic Article	Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver.
Academic Article	Proteomic Analysis of ABCA1-Null Macrophages Reveals a Role for Stomatin-Like Protein-2 in Raft Composition and Toll-Like Receptor Signaling.
Academic Article	Biogenesis and cytotoxicity of APOL1 renal risk variant proteins in hepatocytes and hepatoma cells.
Academic Article	LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling.
Academic Article	Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease.
Academic Article	A Systematic Investigation of Structure/Function Requirements for the Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein.
Academic Article	Myeloid Deletion of a1AMPK Exacerbates Atherosclerosis in LDL Receptor Knockout (LDLRKO) Mice.
Academic Article	Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice.
Academic Article	MicroRNA-33 Regulates the Innate Immune Response via ATP Binding Cassette Transporter-mediated Remodeling of Membrane Microdomains.
Academic Article	In vivo activation of leukocyte GPR120/FFAR4 by PUFAs has minimal impact on atherosclerosis in LDL receptor knockout mice.
Grant	EFFECT OF N-3 FATTY ACIDS ON HDL LIPID INTERACTION
Grant	Hepatocyte Abca1, cholesterol trafficking, and lipid mobilization
Grant	Macrophage, ABCA1, Inflammation, and Atherosclerosis
Grant	ATHEROGENIC PROPERTIES OF LOW DENSITY LIPOPROTEINS
Grant	Integrative Lipid Metabolism, Inflammation, and Chronic Diseases
Grant	LCAT, Lipids, and Atherosclerosis
Grant	2016 Lipoprotein Metabolism Gordon Research Conference and Gordon Research Seminar
Academic Article	Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis.
Academic Article	Hepatic ABCA1 deficiency is associated with delayed apolipoprotein B secretory trafficking and augmented VLDL triglyceride secretion.
Academic Article	Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis.
Academic Article	?-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators.
Academic Article	Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer.
Academic Article	LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis.
Academic Article	Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity.
Academic Article	Tpcn2 knockout mice have improved insulin sensitivity and are protected against high-fat diet-induced weight gain.
Academic Article	Targeted Deletion of Hepatocyte Abca1 Increases Plasma HDL (High-Density Lipoprotein) Reverse Cholesterol Transport via the LDL (Low-Density Lipoprotein) Receptor.
Academic Article	Solute Carrier Family 37 Member 2 (SLC37A2) Negatively Regulates Murine Macrophage Inflammation by Controlling Glycolysis.
Academic Article	Human GDPD3 overexpression promotes liver steatosis by increasing lysophosphatidic acid production and fatty acid uptake.
Academic Article	Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis.
Academic Article	APOL1 Kidney-Risk Variants Induce Mitochondrial Fission.
Academic Article	Exploiting three-dimensional human hepatic constructs to investigate the impact of rs174537 on fatty acid metabolism.
Academic Article	Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein.
Academic Article	The effects of brewers' spent grain on high-fat diet-induced fatty liver.
Academic Article	APOL1 Risk Variants Impair Multiple Mitochondrial Pathways in a Metabolomics Analysis.
Academic Article	Multi-omics Analyses Identify AKR1A1 as a Biomarker for Diabetic Kidney Disease.

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